KIRREL Protein (His tag)

N° du produit ABIN7320809

Détail du produit

Antigène: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette KIRREL protéine est marqué à la His tag.

Fonction: Recombinant Mouse KIRREL1/NEPH1 Protein (His Tag)

Séquence: Leu48-Leu525

Attributs du produit: Recombinant Mouse KIRREL1 is produced by our Mammalian expression system and the target gene encoding Leu48-Leu525 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: KIRREL (NEPH1) (Kin of IRRE Like 1 (NEPH1))

Autre désignation: KIRREL1/NEPH1 (NEPH1 Produits)

Synonymes: NEPH1 Protein, 6720469N11Rik Protein, Kirrel1 Protein, Neph1 Protein, nephrin related Protein, kirre like nephrin family adhesion molecule 1 Protein, kin of IRRE like (Drosophila) Protein, Smp_104390 Protein, Smp_140170 Protein, KIRREL1 Protein, Kirrel Protein, Kirrel1 Protein

Sujet:

Background: Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like protein 1(Neph1), belongs to the immunoglobulin superfamily. Kirrel1 plays a significant role in the normal development and function of the glomerular permeability. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. The knockout of this gene could result in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli. Its' subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains). This interaction is dependent on KIRREL glycosylation. Kirrel1 also interacts when tyrosine-phosphorylated with GRB2.

Synonym: Kin of IRRE-like protein 1,Kin of irregular chiasm-like protein 1,Nephrin-like protein 1,Kirrel1,Neph1

Poids moléculaire: 53.4 kDa

UniProt: Q80W68

Pathways: Regulation of Actin Filament Polymerization