KIT Ligand Protein (KITLG) (His tag)

N° du produit ABIN7321269

Cette protéine Recombinant KIT Ligand est produite dans Human Cells.

Aperçu rapide pour KIT Ligand Protein (KITLG) (His tag) (ABIN7321269)

Antigène: KIT Ligand (KITLG)

Type de proteíne: Recombinant

Origine: Rat

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette KIT Ligand protéine est marqué à la His tag.

Fonction: Recombinant Rat SCF/c-Kit Ligand Protein (Human Cells, His Tag)

Séquence: Gln26-Ala189

Attributs du produit: Recombinant Rat SCF is produced by our Mammalian expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: KIT Ligand (KITLG)

Autre désignation: SCF/c-Kit Ligand

Sujet:

Background: SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.

Synonym: FPH2, KIT ligand, Kitl, KITLG, KL-1, Mast cell growth factor, MGF, MGFSHEP7, SCF, SFc-Kit ligand, SLF, steel factor, Stem Cell Factor, c-kit Ligand

Poids moléculaire: 19.4 kDa

UniProt: P21581

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway