LILRA5 Protein (His tag)

N° du produit ABIN7319539

Détail du produit

Antigène: LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette LILRA5 protéine est marqué à la His tag.

Fonction: Recombinant Human LILRA5 Protein (His Tag)

Séquence: Gly42-Arg268

Attributs du produit: Recombinant Human LILRA5 Member 5 is produced by our Mammalian expression system and the target gene encoding Gly42-Arg268 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: LILRA5 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 5 (LILRA5))

Autre désignation: LILRA5 (LILRA5 Produits)

Synonymes: CD85 Protein, CD85F Protein, ILT-11 Protein, ILT11 Protein, LILRB7 Protein, LIR-9 Protein, LIR9 Protein, E030017K20 Protein, EG232801 Protein, Gm4878 Protein, Lilrc1 Protein, leukocyte immunoglobulin like receptor A5 Protein, leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 Protein, LILRA5 Protein, Lilra5 Protein

Sujet:

Background: Leukocyte Immunoglobulin-like Receptor Subfamily A Member 5(LILRA5)is a member of the leukocyte immunoglobulin-like receptors (LILR), comprise a family of activating and inhibitory type immunoreceptors. LILRA5 consists of a 227 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 10 aa cytoplasmic tail. The ECD contains two Ig-like domains and the transmembrane segment contains a positively charged aspartic acid residue which may mediate its association with the signaling molecule, FcR common gamma chain. LILRA5 is expressed by monocytes, macrophages, and neutrophils. Cross-linking of LILRA5 on monocytes induces the expression of pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) as well as the anti-inflammatory IL-10. It can be detected in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Crosslink of ILT-11 on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.

Synonym: Leukocyte immunoglobulin-like receptor subfamily A member 5, CD85 antigen-like family member F, Immunoglobulin-like transcript 11, ILT-11, Leukocyte immunoglobulin-like receptor 9, LIR-9, CD85f, LILRA5, LILRB7,CD85F,ILT11,LILRB7,LIR-9,LIR9

Poids moléculaire: 26.1 kDa

UniProt: A6NI73