LAIR1 Protein (mFc Tag)

N° du produit ABIN7319831

Détail du produit

Antigène: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette LAIR1 protéine est marqué à la mFc Tag.

Fonction: Recombinant Human Leukocyte-associated Immunoglobulin-like Receptor 1/LAIR1/CD305 (C-mFc)

Séquence: Gln22-His163

Attributs du produit: Recombinant Human Leukocyte-Associated Immunoglobulin-Like Receptor 1 is produced by our Mammalian expression system and the target gene encoding Gln22-His163 is expressed with a mFc tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1))

Autre désignation: Leukocyte-associated Immunoglobulin-like Receptor 1/LAIR1/CD305 (LAIR1 Produits)

Synonymes: 5133400O11Rik Protein, BB115266 Protein, D7Bwg0421e Protein, Lair-1 Protein, mLair-1 Protein, CD305 Protein, LAIR-1 Protein, leukocyte-associated Ig-like receptor 1 Protein, leukocyte associated immunoglobulin like receptor 1 Protein, leukocyte-associated immunoglobulin-like receptor 1 Protein, Lair1 Protein, LAIR1 Protein

Sujet:

Background: Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.

Synonym: Leukocyte-Associated Immunoglobulin-Like Receptor 1, LAIR-1, hLAIR1, CD305, LAIR1

Poids moléculaire: 41.8 kDa

UniProt: Q6GTX8