LY86 Protein (His tag)

N° du produit ABIN7320457

Détail du produit

Antigène: LY86 (Lymphocyte Antigen 86 (LY86))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette LY86 protéine est marqué à la His tag.

Fonction: Recombinant Mouse MD1 Protein (His Tag)

Séquence: Met 1-Ser 162

Attributs du produit: A DNA sequence encoding the extracellular domain (Met 1-Ser 162) of mouse LY86 (NP_034875.1) precursor was expressed with a C-terminal polyhistidine tag.

Pureté: > 92 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: LY86 (Lymphocyte Antigen 86 (LY86))

Autre désignation: MD1 (LY86 Produits)

Synonymes: MD-1 Protein, MMD-1 Protein, dJ80N2.1 Protein, MD1 Protein, LY86 Protein, lymphocyte antigen 86 Protein, LY86 Protein, Ly86 Protein

Sujet:

Background: MD-1 and MD-2 are secretory glycoproteins that exist on the cell surface in complexes with transmembrane proteins. MD-1 is anchored by radioprotective 105 (RP105) which is a molecule containing leucine-rich repeats and is expressed on B cells, dentritic cells and macrophages, while MD-2 is associated with TLR4. MD-1 is required for efficient RP105 cell surface expression and function. It is indicated that the RP105/MD1 complex, in conjunction with TLR4, mediates the innate immune response to LPS in B cells, and also plays a role in protecting against apoptosis, B-cell proliferation, etc. Mouse MD-1 cDNA encodes a 162 amino acid precursor protein with a putative 19 aa signal peptide and two potential N-linked glycosylation sites. It shares 40 % and 66 % amino acid sequence identity with chicken and human MD-1 respectively. MD-1 is mainly expressed in spleen, and also detectable in liver, brain, thymus, and kidney.

Synonym: MD-1,MD1

Poids moléculaire: 18 kDa

NCBI Accession: NP_034875

Pathways: Toll-Like Receptors Cascades