MAP4K2 Protein (GST tag,His tag)

N° du produit ABIN7317061

Détail du produit

Antigène: MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette MAP4K2 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human MAP4K2/GC Kinase Protein (His & GST Tag)

Séquence: Met 1-Tyr 812

Attributs du produit: A DNA sequence encoding the human MAP4K2 (AAH47865.1) (Met 1-Tyr 812) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 87 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))

Autre désignation: MAP4K2/GC Kinase (MAP4K2 Produits)

Synonymes: BL44 Protein, GCK Protein, RAB8IP Protein, AI385662 Protein, Rab8ip Protein, MAP4K2 Protein, dZ150L22.2 Protein, map4k2l Protein, map4k2l-2 Protein, map4k3l Protein, si:dz150l22.2 Protein, si:dz263j20.1 Protein, zgc:136670 Protein, mitogen-activated protein kinase kinase kinase kinase 2 Protein, mitogen activated protein kinase kinase kinase kinase 2 Protein, MAP4K2 Protein, Map4k2 Protein, LOC103346779 Protein, map4k2 Protein

Sujet:

Background: Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein and MAP4K2, is a cytoplasm and peripheral membrane protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. MAP4K2 can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. It is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1 / MEKK1. MAP4K2 enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. It may also play a role in the regulation of vesicle targeting or fusion.

Synonym: BL44;GCK;MAP4K2;RAB8IP

Poids moléculaire: 119 kDa