MAP4K5 Protein (GST tag,His tag)

N° du produit ABIN7317063

Détail du produit

Antigène: MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette MAP4K5 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human MAP4K5/MEKKK5 Protein (His & GST Tag)

Séquence: Met 1-Tyr 846

Attributs du produit: A DNA sequence encoding the human MAP4K5 (NP_006566.2) (Met 1-Tyr 846) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 82 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 0.5 mM TCEP, pH 8.5

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5))

Autre désignation: MAP4K5/MEKKK5 (MAP4K5 Produits)

Synonymes: GCKR Protein, KHS Protein, KHS1 Protein, MAPKKKK5 Protein, 4432415E19Rik Protein, RGD1562028 Protein, fl74c10 Protein, wu:fl74c10 Protein, zgc:55719 Protein, zgc:55985 Protein, mitogen-activated protein kinase kinase kinase kinase 5 Protein, mitogen-activated protein kinase kinase kinase kinase 5 S homeolog Protein, MAP4K5 Protein, Map4k5 Protein, map4k5 Protein, map4k5.S Protein

Sujet:

Background: Mitogen-activated protein kinase kinase kinase kinase 5, also known as Kinase homologous to SPS1/STE20, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5 and MAP4K5, is a cytoplasm protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. MAP4K5 is ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate. It contains one CNH domain and one protein kinase domain. MAP4K5 is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. MAP4K5 has been shown to interact with CRKL and TRAF2. This kinase was shown to activate Jun kinase in mammalian cells. MAP4K5 is an early component of MAP kinase signal cascades. It may play a role in the response to environmental stress. MAP4K5 appears to act upstream of the JUN N-terminal pathway.

Synonym: GCKR;KHS;KHS1;MAPKKKK5

Poids moléculaire: 123 kDa

NCBI Accession: NP_006566