N6AMT1 Protein (His tag)

N° du produit ABIN7317384

Détail du produit

Antigène: N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1 (Putative) (N6AMT1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette N6AMT1 protéine est marqué à la His tag.

Fonction: Recombinant Human N6AMT1/HEMK2 Protein (His Tag)

Séquence: Met 1-Ser 186

Attributs du produit: A DNA sequence encoding the mature form of human N6AMT1 (AAH11554.1) (Met 1-Ser 186) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1 (Putative) (N6AMT1))

Autre désignation: N6AMT1/HEMK2 (N6AMT1 Produits)

Synonymes: HEMK2 Protein, C21orf127 Protein, N6AMT1 Protein, MTQ2 Protein, N6AMT Protein, 5830445C04Rik Protein, Hemk2 Protein, Pred28 Protein, RGD1311843 Protein, N-6 adenine-specific DNA methyltransferase 1 (putative) Protein, N-6 adenine-specific DNA methyltransferase 1 Protein, HemK methyltransferase family member 2 Protein, uncharacterized LOC100283871 Protein, N6AMT1 Protein, CpipJ_CPIJ001152 Protein, LOC100283871 Protein, N6amt1 Protein

Sujet:

Background: Pyruvate dehydrogenase kinase, isozyme 1, also known as [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial and PDK1, is a member of the PDK / BCKDK protein kinase family. PDK-1 is expressed predominantly in the heart. It contains one histidine kinase domain. Pyruvate dehydrogenase kinase (PDK) isoforms are molecular switches that downregulate the pyruvate dehydrogenase complex (PDC) by reversible phosphorylation in mitochondria. An inhibitory effect of lipoic acid on PDKs would result in less phosphorylation of E1 and hence increased PDC activity. At least two isoenzymic forms of pyruvate dehydrogenase kinase ( PDK-1 and PDK-2 ) may be involved in the regulation of enzymatic activity of mammalian pyruvate dehydrogenase complex by phosphorylation. PDK-3 appears to have the highest specific activity among the three isoenzymes. PDK-1 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Synonym: C21orf127;HEMK2;m.HsaHemK2P;MTQ2;N6AMT;PRED28

Poids moléculaire: 21.2 kDa