NAALADL1 Protein (His tag)

N° du produit ABIN7317641

Détail du produit

Antigène: NAALADL1 (N-Acetylated alpha-Linked Acidic Dipeptidase-Like 1 (NAALADL1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NAALADL1 protéine est marqué à la His tag.

Fonction: Recombinant Human NAALADL1 Protein (His Tag)

Séquence: Pro 29-Leu 740

Attributs du produit: A DNA sequence encoding the extracellular domain of human NAALADL1 (NP_005459.2) (Pro 29-Leu 740) was expressed, with a polyhistidine tag at the N-terminus.

Pureté: > 97 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: NAALADL1 (N-Acetylated alpha-Linked Acidic Dipeptidase-Like 1 (NAALADL1))

Autre désignation: NAALADL1 (NAALADL1 Produits)

Synonymes: I100 Protein, NAALADASEL Protein, Gm964 Protein, Naaladasel Protein, N-acetylated alpha-linked acidic dipeptidase like 1 Protein, N-acetylated alpha-linked acidic dipeptidase-like 1 Protein, NAALADL1 Protein, Naaladl1 Protein

Sujet:

Background: N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidylpeptidase, is a Single-pass type I I membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. NAALADase L is a chloride-activated, membrane bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.

Synonym: I100,NAALADASEL,NAALADL1

Poids moléculaire: 80 kDa

NCBI Accession: NP_005459