NELL2 Protein (His tag)

N° du produit ABIN7317297

Détail du produit

Antigène: NELL2 (NEL-Like 2 (Chicken) (NELL2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette NELL2 protéine est marqué à la His tag.

Fonction: Recombinant Human NELL2 Protein (His Tag)

Séquence: Met 1-Leu 816

Attributs du produit: A DNA sequence encoding the human NELL2 (Q99435) (Met 1-Leu 816) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 87 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: NELL2 (NEL-Like 2 (Chicken) (NELL2))

Autre désignation: NELL2 (NELL2 Produits)

Synonymes: A330108N19Rik Protein, R75516 Protein, mel91 Protein, nel Protein, NRP2 Protein, nell2 Protein, wu:fj43h11 Protein, zgc:158375 Protein, neural EGFL like 2 L homeolog Protein, NEL-like 2 Protein, neural EGFL like 2 Protein, neural EGFL like 2a Protein, nell2.L Protein, Nell2 Protein, NELL2 Protein, nell2a Protein

Sujet:

Background: OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.Immune CheckpointImmune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: NRP2

Poids moléculaire: 90.4 kDa

UniProt: Q99435