NBL1 Protein (Fc Tag)

N° du produit ABIN7317996

Détail du produit

Antigène: NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist (NBL1))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NBL1 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human NBL1/DAND1 Protein (Fc Tag)(Active)

Séquence: Met 1-Asp 180

Attributs du produit: A DNA sequence encoding the human DAN precursor (NP_005371.1) (Met 1-Asp 180) was expressed with C-terminal fused Fc region of human IgG1.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to inhibit BMP4-induced activity in MC3T3-E1 Mouse osteoblastic cells. The ED50 for this effect is typically 0.2-1.2 μg/ml in the presence of 50 ng/mL of recombinant human BMP4.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist (NBL1))

Autre désignation: NBL1/DAND1 (NBL1 Produits)

Synonymes: D1S1733E Protein, DAN Protein, DAND1 Protein, NB Protein, NO3 Protein, D4H1S1733E Protein, Dana Protein, dand1 Protein, nbl1-a Protein, no3 Protein, 4.1N Protein, Epb41l1 Protein, NBL1 Protein, mKIAA0338 Protein, C1orf151-NBL1 Protein, dan Protein, zgc:77251 Protein, neuroblastoma 1, DAN family BMP antagonist Protein, neuroblastoma, suppression of tumorigenicity 1 Protein, neuroblastoma 1, DAN family BMP antagonist L homeolog Protein, neuroblastoma suppressor of tumorigenicity 1 Protein, erythrocyte membrane protein band 4.1 like 1 Protein, MINOS1-NBL1 readthrough Protein, NBL1 Protein, Nbl1 Protein, nbl1.L Protein, LOC535280 Protein, Epb41l1 Protein, MINOS1-NBL1 Protein, nbl1 Protein

Sujet:

Background: The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. It is a founding member of the DAN family of secreted proteins, acts as an inhibitor of cell cycle progression and is closely involved in retinoic acid-induced neuroblastoma differentiation. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante and PRDC (protein related to DAN and cereberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways. It binds to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. DAN gene product may have an important role in regulation of the entry of cells into the S phase. In addition, DAN gene product possesses an ability to revert phenotypes of transformed rat fibroblasts and represents a candidate tumour suppressor gene for neuroblastoma.

Synonym: D1S1733E,DAN,DAND1,NB,NO3

Poids moléculaire: 44.4 kDa

NCBI Accession: NP_005371