NEGR1 Protein (His tag)

N° du produit ABIN7317632

Détail du produit

Antigène: NEGR1 (Neuronal Growth Regulator 1 (NEGR1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NEGR1 protéine est marqué à la His tag.

Fonction: Recombinant Human NEGR1 Protein (His Tag)

Séquence: Met 1-Gly 324

Attributs du produit: A DNA sequence encoding the human NEGR1 (NP_776169.2) (Met 1-Gly 324) without the propeptide was expressed, with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: NEGR1 (Neuronal Growth Regulator 1 (NEGR1))

Autre désignation: NEGR1 (NEGR1 Produits)

Synonymes: zgc:100871 Protein, NEGR1 Protein, Ntra Protein, kilon Protein, DMML2433 Protein, IGLON4 Protein, KILON Protein, 5330422G01Rik Protein, mKIAA3001 Protein, NTRA-L Protein, NTRA-S Protein, neuronal growth regulator 1 Protein, neuronal growth regulator 1 L homeolog Protein, negr1 Protein, NEGR1 Protein, negr1.L Protein, Negr1 Protein

Sujet:

Background: Neuronal Growth Regulator 1, NEGR1, also known as neurotractin, or KILON, which belongs to the immunoglobulin superfamily, IgLON family. This GPI-linked cell surface glycoprotein NEGR1 is composed of three Ig-like domains and belongs to the IgLON subgroup of neural IgSF members. It is expressed in two isoforms with apparent molecular masses of 50 and 37 kD, termed L-form and S-form, respectively. NEGR1/Neurotractin participates in the regulation of neurite outgrowth in the developing brain, and is expressed on neurites of primary hippocampal neurons. Neurotractin/KILON is a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation. KILON (kindred of IgLON) and opioid-binding cell adhesion molecule belong to the IgLON subgroup of immunoglobulin superfamily together with the limbic system-associated membrane protein and neurotrimin. The alteration of modulatory function of KILON/NEGR1 for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development. In addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.

Synonym: DMML2433,IGLON4,KILON,Ntra

Poids moléculaire: 32.9 kDa

NCBI Accession: NP_776169

Pathways: Feeding Behaviour