NETO1 Protein (His tag)

N° du produit ABIN7317535

Détail du produit

Antigène: NETO1 (Neuropilin (NRP) and Tolloid (TLL)-Like 1 (NETO1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NETO1 protéine est marqué à la His tag.

Fonction: Recombinant Human NETO1/BTCL1 Protein (His Tag)

Séquence: Met 1-Thr 344

Attributs du produit: A DNA sequence encoding the human NETO1 isoform 3 (NP_620416.1) extracellular domain (Met 1-Thr 344) was fused with a polyhistidine tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: NETO1 (Neuropilin (NRP) and Tolloid (TLL)-Like 1 (NETO1))

Autre désignation: NETO1/BTCL1 (NETO1 Produits)

Synonymes: BCTL1 Protein, BTCL1 Protein, AI851453 Protein, Btcl1 Protein, C130005O10Rik Protein, RGD1566269 Protein, neuropilin and tolloid like 1 Protein, neuropilin (NRP) and tolloid (TLL)-like 1 Protein, NETO1 Protein, Neto1 Protein

Sujet:

Background: Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- and LDLa-containing proteins. The cytoplasmic domains of NETO1 and NETO2 are not homologous to other known protein sequences but contain a conserved FXNPXY-like motif, which is essential for the internalization of clathrin coated pits during endocytosis or alternatively, may be implicated in intracellular signaling pathways. NETO1 and NETO2, have marked effects on receptor properties, increasing further the potential diversity of Kainate receptors (KARs) functional properties. NETO1 involves in the development and/or maintenance of neuronal circuitry. NETO1 regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.

Synonym: BCTL1,BTCL1

Poids moléculaire: 38 kDa

NCBI Accession: NP_620416

Pathways: Regulation of long-term Neuronal Synaptic Plasticity