NCF1 Protein (His tag)

N° du produit ABIN7318825

Détail du produit

Antigène: NCF1 (Neutrophil Cytosol Factor 1 (NCF1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette NCF1 protéine est marqué à la His tag.

Fonction: Recombinant Human Neutrophil Cytosol Factor 1/NCF1 Protein (His Tag)

Séquence: Met 1-Val390

Attributs du produit: Recombinant Human Neutrophil cytosol factor 1 is produced by our E.coli expression system and the target gene encoding Met1-Val390 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris 100 mM NaCl,1 mM DTT, pH 8.0.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: NCF1 (Neutrophil Cytosol Factor 1 (NCF1))

Autre désignation: Neutrophil Cytosol Factor 1/NCF1 (NCF1 Produits)

Synonymes: NCF1A Protein, NOXO2 Protein, SH3PXD1A Protein, p47phox Protein, Ncf-1 Protein, p47 Protein, neutrophil cytosolic factor 1 Protein, NCF1 Protein, Ncf1 Protein

Sujet:

Background: Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and plays an important role in innate immunity, producing reactive oxygen species and reducing the severity and duration of parasitic infection and autoimmune disease. NCF1 also has a role in T cell activation.

Synonym: NCF-1,47 kDa autosomal chronic granulomatous disease protein/47 kDa neutrophil oxidase factor,NCF-47K,Neutrophil NADPH oxidase factor 1,Nox organizer 2,Nox-organizing protein 2/SH3 and PX domain-containing protein 1A,p47-phox

Poids moléculaire: 45.6 kDa

UniProt: P14598

Pathways: Signalisation PI3K-Akt