OXSR1 Protein (GST tag)

N° du produit ABIN7197261

Détail du produit

Antigène: OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette OXSR1 protéine est marqué à la GST tag.

Fonction: Recombinant Human OXSR1/OSR1 Protein (GST Tag)

Séquence: Met 1-Ser 527

Attributs du produit: A DNA sequence encoding the full length of human OXSR1 (NP_005100.1) (Met 1-Ser 527) was fused with the GST tag at the N-terminus.

Pureté: > 88 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 50 mM Tris, 100 mM NaCl, pH 8.0, 0.5 mM GSH, 0.5 mM PMSF, 0.5 mM EDTA, 10 % glycerol

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: OXSR1 (Oxidative-Stress Responsive 1 (OXSR1))

Autre désignation: OXSR1/OSR1 (OXSR1 Produits)

Synonymes: OSR1 Protein, C20orf111 Protein, HSPC207 Protein, Osr1 Protein, Perit1 Protein, dJ1183I21.1 Protein, zgc:55494 Protein, zgc:77321 Protein, OXSR1 Protein, 2210022N24Rik Protein, 2810422B09Rik Protein, AI462649 Protein, AW209236 Protein, mKIAA1101 Protein, odd1 Protein, osr1 Protein, wu:fb77f12 Protein, zgc:165661 Protein, oxidative stress responsive 1 Protein, oxidative stress responsive serine rich 1 Protein, oxidative stress responsive 1b Protein, serine/threonine-protein kinase OSR1 Protein, odd-skipped related transciption factor 1 Protein, oxidative-stress responsive 1 Protein, oxidative stress responsive 1a Protein, OXSR1 Protein, OSER1 Protein, oxsr1b Protein, CpipJ_CPIJ015177 Protein, Tsp_00299 Protein, OSR1 Protein, Oxsr1 Protein, LOC106505565 Protein, oxsr1 Protein, oxsr1a Protein

Sujet:

Background: Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39 % identical to that of human SOK1. Of potential regulators surveyed, endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 did not increase the activity of coexpressed JNK, nor did it activate three other MAPKs, p38, ERK2, and ERK5. Phosphorylation by OXSR1 modulates the G protein sensitivity of PAK isoforms. The OXSR1 and SPAK are key enzymes in a signalling cascade regulating the activity of Na+/K+/2Cl- co-transporters (NKCCs) in response to osmotic stress. Both kinases have a conserved carboxy-terminal (CCT) domain, which recognizes a unique peptide (Arg-Phe-Xaa-Val) motif. The OXSR1 and SPAK kinases specifically recognize their upstream activators and downstream substrates.

Synonym: OSR1

Poids moléculaire: 84 kDa

NCBI Accession: NP_005100

Pathways: Tube Formation