PLA2G2D Protein (Fc Tag)

N° du produit ABIN7197351

Détail du produit

Antigène: PLA2G2D (Phospholipase A2, Group IID (PLA2G2D))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PLA2G2D protéine est marqué à la Fc Tag.

Fonction: Recombinant Human PLA2G2D Protein (Fc Tag)

Séquence: Met 1-Cys145

Attributs du produit: A DNA sequence encoding the human PLA2G2D (Q9UNK4) (Met1-Cys145) was expressed with the Fc region of human IgG1 at the C-terminus.

Pureté: > 85 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: PLA2G2D (Phospholipase A2, Group IID (PLA2G2D))

Autre désignation: PLA2G2D (PLA2G2D Produits)

Synonymes: PLA2IID Protein, SPLASH Protein, sPLA2-IID Protein, sPLA2S Protein, Splash Protein, mGIID Protein, phospholipase A2 group IID Protein, phospholipase A2, group IID Protein, PLA2G2D Protein, Pla2g2d Protein

Sujet:

Background: The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48- kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST/OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto the asparagine acceptor site within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains across the membrane of the endoplasmic reticulum. The mammalian oligosaccharyltransferase (OST) is an oligomeric complex composed of three type I transmembrane proteins of the endoplasmic reticulum: ribophorin I (RI), ribophorin II (RII), and OST48. OST48 is not a glycoprotein and is not recognized by antibodies to either ribophorin. Like ribophorins I and II, OST48 was found to be an integral membrane protein, with the majority of the polypeptide located within the lumen of the endoplasmic reticulum (ER). OST48 does not show significant amino acid sequence homology to either ribophorin I or II. It had been found that only the luminal domain of RI contains ER retention information. The dilysine motif in OST48 functions as an ER localization motif because OST48 in which the two lysine residues are replaced by serine (OST48ss) is no longer retained in the ER and is found instead also at the plasma membrane.

Synonym: PLA2IID,sPLA2-IID,sPLA2S,SPLASH

Poids moléculaire: 41.5 kDa

UniProt: Q9UNK4

Pathways: Inositol Metabolic Process