PTPRN Protein (AA 687-979) (His tag)

N° du produit ABIN7318592

Détail du produit

Antigène: PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))

Type de proteíne: Recombinant

Attributs du protein: AA 687-979

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PTPRN protéine est marqué à la His tag.

Fonction: Recombinant Human IA2/PTPRN Protein (aa 687-979, His Tag)

Séquence: Met687-Gln979

Attributs du produit: Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N is produced by our E.coli expression system and the target gene encoding Met687-Gln979 is expressed with a 6His tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: PTPRN (Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN))

Autre désignation: IA2/PTPRN (PTPRN Produits)

Synonymes: IA-2 Protein, IA-2/PTP Protein, IA2 Protein, ICA512 Protein, R-PTP-N Protein, mIA-A Protein, mKIAA4064 Protein, Ia-2 Protein, fc43c04 Protein, ptprn Protein, wu:fc43c04 Protein, ia-2 Protein, ia2 Protein, ica512 Protein, r-ptp-n Protein, protein tyrosine phosphatase, receptor type N Protein, protein tyrosine phosphatase, receptor type, N Protein, protein tyrosine phosphatase, receptor type, Na Protein, protein tyrosine phosphatase, receptor type N L homeolog Protein, PTPRN Protein, Ptprn Protein, ptprna Protein, ptprn.L Protein

Sujet:

Background: Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

Synonym: Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512

Poids moléculaire: 35.6 kDa

UniProt: Q16849