PTMA Protein (GST tag)

N° du produit ABIN7317565

Détail du produit

Antigène: PTMA (Prothymosin, alpha (PTMA))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette PTMA protéine est marqué à la GST tag.

Fonction: Recombinant Human PTMA Protein (GST Tag)

Séquence: Ser 2-Asp 111

Attributs du produit: A DNA sequence encoding the human PTMA (P06454-1) (Ser 2-Asp 111) was fused with the GST tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: PTMA (Prothymosin, alpha (PTMA))

Autre désignation: PTMA (PTMA Produits)

Synonymes: TMSA Protein, ptma Protein, MGC64300 Protein, tmsa Protein, Thym Protein, ptma-a Protein, ptma-b Protein, prothymosin, alpha Protein, prothymosin, alpha L homeolog Protein, prothymosin alpha Protein, prothymosin, alpha S homeolog Protein, PTMA Protein, ptma.L Protein, ptma Protein, Ptma Protein, ptma.S Protein

Sujet:

Background: PTMA (prothymosin, alpha, N-GST chimera) is a small, 12.4 kDa protein. It is a 109-111 amino acid long polypeptide as the precursor of thymosin a1. Thymosins are named becaues they were originally isolated from the thymus. But now in many other tissues, thymosins also can be detected. Thymosins have diverse biological activities, and two in particular, thymosins a1 and _4, have potentially important uses in medicine, some of which have already progressed from the laboratory to the clinic. In general, PTMA is associated with cellular proliferation and carcinogenesis (Eschenfeldt et al., 1986), cellular and viral transcription (Cotter et al., 2000), protection against apoptosis and chromatin remodelling (Karetsou et al., 1998). PTMA may have a dual role both intracellulary and extracellulary. In relation to diseases, thymosins have been categorized as biological response modifiers. Thymosin a1 is derived from PTMA. For animals that lack thymus glands, thymosin a1 is responsible for the activity of that preparation in restoring immune function.

Synonym: TMSA

Poids moléculaire: 39 kDa