PCBD1 Protein (His tag)
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- Antigène Voir toutes PCBD1 Protéines
- PCBD1 (Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1))
- Type de proteíne
- Recombinant
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette PCBD1 protéine est marqué à la His tag.
- Fonction
- Recombinant Human PCBD1 Protein (His Tag)
- Séquence
- Ala2-Thr104
- Attributs du produit
- Recombinant Human Pterin-4-alpha-Carbinolamine Dehydratase is produced by our E.coli expression system and the target gene encoding Ala2-Thr104 is expressed with a 6His tag at the N-terminus.
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PCBD1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, 1 mM DTT, pH 8.0.
- Stock
- -20 °C
- Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Antigène
- PCBD1 (Pterin-4 alpha-Carbinolamine Dehydratase/dimerization Cofactor of Hepatocyte Nuclear Factor 1 alpha (PCBD1))
- Autre désignation
- PCBD1 (PCBD1 Produits)
- Synonymes
- BcDNA:LP07248 Protein, CG1963 Protein, Dmel\\CG1963 Protein, PCD Protein, pcbd Protein, zgc:73389 Protein, Xdcoh Protein, dcoh Protein, pcd Protein, phs Protein, DDBDRAFT_0204977 Protein, DDBDRAFT_0305045 Protein, DDB_0204977 Protein, DDB_0305045 Protein, Dcoh Protein, Pcbd Protein, DCOH Protein, PHS Protein, PCBD Protein, DCoH Protein, TCF1 Protein, pterin-4a-carbinolamine dehydratase Protein, pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha Protein, pterin-4-alpha-carbinolamine dehydratase Protein, pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 Protein, pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha L homeolog Protein, pterin-4 alpha-carbinolamine dehydratase 1 Protein, Pcd Protein, pcbd1 Protein, Tb11.02.4890 Protein, pcbd Protein, Fbal_2579 Protein, Ftrac_2004 Protein, Celal_2911 Protein, Isop_1133 Protein, Celly_0291 Protein, Pcbd1 Protein, pcbd1.L Protein, PCBD1 Protein
- Sujet
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Background: Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.
Synonym: Pterin-4-Alpha-Carbinolamine Dehydratase, PHS, 4-Alpha-Hydroxy-Tetrahydropterin Dehydratase, Dimerization Cofactor of Hepatocyte Nuclear Factor 1-Alpha, DCoH, Dimerization Cofactor of HNF1, Phenylalanine Hydroxylase-Stimulating Protein, Pterin Carbinolamine Dehydratase, PCD, PCBD1, DCOH, PCBD
- Poids moléculaire
- 14.2 kDa
- UniProt
- P61457
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