PDK4 Protein (AA 1-412) (His-GST)

N° du produit ABIN7320000

Cette protéine Recombinant PDK4 est produite dans Baculovirus infected Insect Cells.

Aperçu rapide pour PDK4 Protein (AA 1-412) (His-GST) (ABIN7320000)

Antigène: PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Baculovirus infected Insect Cells

Pureté: > 85 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 1-412

Purification/Conjugué: Cette PDK4 protéine est marqué à la His-GST.

Fonction: Recombinant Mouse PDK4 Protein (His & GST Tag)

Séquence: Met1-Val412

Attributs du produit: A DNA sequence encoding the mouse PDK4 (O70571) (Met1-Val412) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Kinase activity untested

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Autre désignation: PDK4

Sujet: AV005916,Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxidation via the phosphorylation of pyruvate dehydrogenase complex (PDC).PDK4 gene expression is stimulated by thyroid hormone (T(3)), glucocorticoids, and long chain fatty acids.

Poids moléculaire:

Calculated MW: 74.4 kDa

Observed MW: 65 kDa

UniProt: O70571

Pathways: Signalisation PI3K-Akt, Signalisation Hedgehog, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg