RBP4 Protein (His tag)

N° du produit ABIN7321242

Détail du produit

Antigène: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette RBP4 protéine est marqué à la His tag.

Fonction: Recombinant Rat RBP4 Protein (His Tag)(Active)

Séquence: Met 1-Leu 201

Attributs du produit: A DNA sequence encoding the extracellular domain of rat RBP4 (NP_037294.1) (Met 1-Leu 201) was expressed, fused with a polyhistidine tag at the C-terminus.

Pureté: > 97 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method

Biological Activity Comment: Measured by its ability to bind alltrans retinoic acid. The binding of retinoic acid results in the quenching of Trp fluorescence in RBP4.The 50% binding concentration (BC50) is >0.5 μM.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Autre désignation: RBP4 (RBP4 Produits)

Synonymes: RDCCAS Protein, RBP Protein, RNBP Protein, rbp4 Protein, MGC54038 Protein, srbp Protein, PRBP Protein, RBPA Protein, Rbp-4 Protein, fb23c12 Protein, rbp Protein, wu:fb23c12 Protein, wu:fb58d04 Protein, wu:fb72b04 Protein, zgc:86911 Protein, retinol binding protein 4 Protein, renin binding protein Protein, retinol binding protein 4 S homeolog Protein, retinol binding protein 4 A, plasma Protein, retinol binding protein 4, plasma Protein, retinol binding protein 4 L homeolog Protein, RBP4 Protein, RENBP Protein, rbp4.S Protein, rbp4 Protein, Rbp4 Protein, RBP4A Protein, rbp4.L Protein

Sujet:

Background: Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).

Synonym: RBPA;Rbp4

Poids moléculaire: 22.8 kDa

NCBI Accession: NP_037294

Pathways: Regulatory RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response