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SLPI Protein (AA 26-132) (His tag)

SLPI Origine: Humain Hôte: Baculovirus infected Insect Cells Recombinant > 84 % as determined by reducing SDS-PAGE. Active
N° du produit ABIN7197865
  • Antigène Voir toutes SLPI Protéines
    SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    AA 26-132
    Origine
    • 7
    • 4
    • 1
    • 1
    Humain
    Source
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Baculovirus infected Insect Cells
    Purification/Conjugué
    Cette SLPI protéine est marqué à la His tag.
    Fonction
    Recombinant Human SLPI Protein (aa 26-132, His Tag)(Active)
    Séquence
    Ser 26-Ala 132
    Attributs du produit
    A DNA sequence encoding the secreted form of human SLPI (P03973) (Ser 26-Ala 132) was expressed, with a polyhistidine tag at the N-terminus.
    Pureté
    > 84 % as determined by reducing SDS-PAGE.
    niveau d'endotoxine
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2 (Catalog # ES002).The IC50 value is <4 Nm.
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    Discover our top product SLPI Protéine
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
    Stock
    4 °C,-20 °C,-80 °C
    Stockage commentaire
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Antigène
    SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
    Autre désignation
    SLPI (SLPI Produits)
    Synonymes
    ALK1 Protein, ALP Protein, BLPI Protein, HUSI Protein, HUSI-I Protein, MPI Protein, WAP4 Protein, WFDC4 Protein, MATN4 Protein, SLPI Protein, ckpi Protein, secretory leukocyte peptidase inhibitor Protein, antileukoproteinase Protein, SLPI Protein, Slpi Protein, LOC102174044 Protein
    Sujet

    Background: Secretory leukoprotease inhibitor (SLPI), also called antileukoprotease (ALP), is a 12- kDa, nonglycosylated serine protease inhibitor present in mucous secretions. It is thought to play a role in protecting the mucosae from injury associated with inflammation. SLPI is locally produced by serous cells, including bronchial submucosal glands. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. Elafin and SLPI are structurally related in that both have a fold with a four-disulfide core or whey acidic protein (WAP) domain responsible for inhibiting proteases. SLPI is a prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity.

    Synonym: ALK1,ALP,BLPI,HUSI,HUSI-I,MPI,WAP4,WFDC4

    Poids moléculaire
    14 kDa
    UniProt
    P03973
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