STK10-A Protein (His tag)

N° du produit ABIN7317065

Détail du produit

Antigène: STK10-A (Serine/threonine Kinase 10 (STK10-A))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette STK10-A protéine est marqué à la His tag.

Fonction: Recombinant Human STK10/LOK Protein (His Tag)(Active)

Séquence: Arg 18-Glu 317

Attributs du produit: A DNA sequence encoding the human STK10 (NP_005981.3) (Arg 18-Glu 317) was expressed, with a polyhistide tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

Biological Activity Comment: The specific activity was determined to be 1353 nmol/min/mg using synthetic AXLtide peptide (KKSRGDYMTMQIG) as substrate.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: STK10-A (Serine/threonine Kinase 10 (STK10-A))

Autre désignation: STK10/LOK (STK10-A Produits)

Synonymes: LOK Protein, PRO2729 Protein, Gek1 Protein, Lok Protein, mKIAA4026 Protein, zgc:63495 Protein, plkk1 Protein, stk10 Protein, xPlkk1 Protein, serine/threonine kinase 10 Protein, serine/threonine kinase 10 S homeolog Protein, STK10 Protein, Stk10 Protein, stk10 Protein, stk10.S Protein

Sujet:

Background: Serine / threonine-protein kinase 10, also known as Lymphocyte-oriented kinase, STK10 and LOK, which belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE20 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste20 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK10 is similar to several known polo-like kinase kinases. It can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. STK10 can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. Stk10 can associate with Plk1 in cells and furthermore can phosphorylate Plk1. It can also act on substrates such as myelin basic protein and histone 2A on serine and threonine residues.

Synonym: LOK;PRO2729

Poids moléculaire: 36 kDa

NCBI Accession: NP_005981