STK40 Protein (GST tag,His tag)

N° du produit ABIN7197936

Détail du produit

Antigène: STK40 (serine/threonine Kinase 40 (STK40))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette STK40 protéine est marqué à la GST tag,His tag.

Fonction: Recombinant Human STK40 Protein (His & GST Tag)

Séquence: Met 1-Lys 435

Attributs du produit: A DNA sequence encoding the human STK40 (NP_114406) (Met1-Lys435) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Pureté: > 97 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, 3 mM DTT, 0.5M Urea, 0.5 mM GSH, pH 8.0

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: STK40 (serine/threonine Kinase 40 (STK40))

Autre désignation: STK40 (STK40 Produits)

Synonymes: cb988 Protein, fd99h11 Protein, wu:fd99h11 Protein, NV14115 Protein, DKFZp459J1924 Protein, RP11-268J15.4 Protein, SHIK Protein, SgK495 Protein, 2310004N11Rik Protein, AI428792 Protein, Lyk4 Protein, RGD1307310 Protein, serine/threonine kinase 40 Protein, serine/threonine kinase 40 L homeolog Protein, STK40 Protein, stk40 Protein, LOC100123745 Protein, Stk40 Protein, stk40.L Protein

Sujet:

Background: STK40 localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ESCs markedly reduces ExEn differentiation in vitro. STK40 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NFκB-mediated gene transcription. Similarly, overexpression of STK40 inhibits NFκB activation triggered by TNF and also inhibits p53-mediated transcription. There are four named isoforms of STK40 that are produced as a result of alternative splicing.

Synonym: SgK495;SHIK

Poids moléculaire: 76.8 kDa

NCBI Accession: NP_114406