SERPINB9 Protein (His tag)

N° du produit ABIN7319269

Détail du produit

Antigène: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Purification/Conjugué: Cette SERPINB9 protéine est marqué à la His tag.

Fonction: Recombinant Human SERPINB9/PI-9 Protein (Human Cells, His Tag)

Séquence: Met 1-Pro376

Attributs du produit: Recombinant Human Serine Protease Inhibitor-clade B9 is produced by our Mammalian expression system and the target gene encoding Met1-Pro376 is expressed with a 6His tag at the C-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Autre désignation: SERPINB9/PI-9 (SERPINB9 Produits)

Synonymes: SERPINB9 Protein, BB283241 Protein, CAP-3 Protein, CAP3 Protein, PI-9 Protein, PI9 Protein, Spi6 Protein, ovalbumin Protein, serpin family B member 9 Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 9 Protein, serine (or cysteine) peptidase inhibitor, clade B, member 9 Protein, Serpinb9 Protein, SERPINB9 Protein

Sujet:

Background: Serpin B9, also known as Cytoplasmic antiproteinase 3(CAP-3), is a cytoplasm protein which belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. Serpin B9 is an inhibitor of the granzyme B/perforin lytic pathway. It is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis. Serpin-B9 expression in immune-privileged cells, APCs, and CTLs protects these cells against the actions of granzyme B, and when expressed in tumor cells or virally infected hepatocytes, confers resistance to killing by CTL and NK cells. Expression of increasing levels of Serpin-B9 in target cells may progressively inhibit immune surveillance by blocking NK and CTL-induced cytotoxicity through the perforin / granzyme pathway and then through the Fas / FasL pathway.

Synonym: Cytoplasmic antiproteinase 3,Peptidase inhibitor 9,CAP3,PI-9,Serpin B9

Poids moléculaire: 43.4 kDa

UniProt: P50453