PEDF Protein (His tag)
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- Antigène Voir toutes PEDF (SERPINF1) Protéines
- PEDF (SERPINF1) (serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1))
- Type de proteíne
- Recombinant
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Origine
- Rat
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette PEDF protéine est marqué à la His tag.
- Fonction
- Recombinant Rat SerpinF1/PEDF Protein (His Tag)
- Séquence
- Met1-Thr418
- Attributs du produit
- A DNA sequence encoding the rat Serpinf1 (NP_808788.1) (Met1-Thr418) was expressed with a polyhistidine tag at the C-terminus.
- Pureté
- > 90 % as determined by SDS-PAGE
- niveau d'endotoxine
- < 1.0 EU per μg protein as determined by the LAL method.
- Top Product
- Discover our top product SERPINF1 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- PEDF (SERPINF1) (serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1))
- Autre désignation
- SerpinF1/PEDF (SERPINF1 Produits)
- Synonymes
- EPC-1 Protein, OI12 Protein, OI6 Protein, PEDF Protein, MGC82984 Protein, SERPINF1 Protein, AI195227 Protein, Pedf Protein, Pedfl Protein, Sdf3 Protein, Dmrs91 Protein, zgc:92072 Protein, serpin family F member 1 Protein, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 Protein, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog Protein, serine (or cysteine) peptidase inhibitor, clade F, member 1 Protein, SERPINF1 Protein, serpinf1 Protein, serpinf1.L Protein, Serpinf1 Protein
- Sujet
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Background: Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.
Synonym: Dmrs91
- Poids moléculaire
- 45.9 kDa
- NCBI Accession
- NP_808788
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