SDPR Protein (AA 2-180) (His tag)

N° du produit ABIN7320219

Détail du produit

Antigène: SDPR (Serum Deprivation Response (SDPR))

Type de proteíne: Recombinant

Attributs du protein: AA 2-180

Origine: Souris

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette SDPR protéine est marqué à la His tag.

Fonction: Recombinant Mouse SDPR Protein (aa 2-180, His Tag)

Séquence: Gly 2-Ala 180

Attributs du produit: A DNA sequence encoding the mouse SDPR (NP_620080.1) N-terminal segment (Gly 2-Ala 180) was expressed, with a polyhistide tag at the N-terminus.

Pureté: > 95 % as determined by SDS-PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4, 30 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SDPR (Serum Deprivation Response (SDPR))

Autre désignation: SDPR (SDPR Produits)

Synonymes: CAVIN2 Protein, PS-p68 Protein, SDR Protein, cavin-2 Protein, sdr Protein, MGC84112 Protein, sdprb Protein, wu:fb39c08 Protein, wu:fk90b02 Protein, zgc:92231 Protein, caveolae associated protein 2 Protein, caveolae associated 2 Protein, caveolae associated protein 2 S homeolog Protein, serum deprivation response Protein, caveolae associated protein 2b Protein, CAVIN2 Protein, Cavin2 Protein, cavin2.S Protein, SDPR Protein, cavin2b Protein

Sujet:

Background: Serum deprivation-response protein, also known as Phosphatidylserine-binding protein, Cavin-2 and SDPR, is a member of the PTRF / SDPR family. SDPR is highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle. SDPR is a new regulator of caveolae biogenesis. SDPR is up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition and Down-regulated during synchronous cell cycle re-entry. Caveolae are plasma membrane invaginations with a characteristic flask-shaped morphology. They function in diverse cellular processes, including endocytosis. Loss of SDPR causes loss of caveolae. SDPR binds directly to PTRF and recruits PTRF to caveolar membranes. Overexpression of SDPR, unlike PTRF, induces deformation of caveolae and extensive tubulation of the plasma membrane. SDPR overexpression results in increased caveolae size and leads to the formation of caveolae-derived tubules containing Shiga toxin. SDPR is a membrane curvature inducing component of caveolae, and that STB-induced membrane tubulation is facilitated by caveolae. Pleckstrin and SDPR are phosphorylated by protein kinase C (PKC), the interaction between pleckstrin and SDPR was shown to be independent of PKC inhibition or activation. SDPR may facilitate the translocation of nonphosphorylated pleckstrin to the plasma membrane in conjunction with phosphoinositides that bind to the C-terminal PH domain.

Synonym: SDPR

Poids moléculaire: 21 kDa

NCBI Accession: NP_620080