SMYD2A Protein (His tag)

N° du produit ABIN7317658

Détail du produit

Antigène: SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette SMYD2A protéine est marqué à la His tag.

Fonction: Recombinant Human SMYD2/KMT3C Protein (His Tag)

Séquence: Met 1-His 433

Attributs du produit: A DNA sequence encoding the full length of human SMYD2 (NP_064582.2) (Met 1-His 433) was expressed, with a polyhistidine tag at the N-terminus.

Pureté: > 97 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tris, 100 mM NaCl, 10 % glycerol, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SMYD2A (SET and MYND Domain Containing 2a (SMYD2A))

Autre désignation: SMYD2/KMT3C (SMYD2A Produits)

Synonymes: HSKM-B Protein, KMT3C Protein, ZMYND14 Protein, 1110020E07Rik Protein, 4930402C15 Protein, Zmynd14 Protein, smyd2-a Protein, im:7146196 Protein, smyd2 Protein, wu:fc02f02 Protein, zgc:110553 Protein, si:dkey-121j17.3 Protein, zgc:136609 Protein, SET and MYND domain containing 2 Protein, SET and MYND domain containing 2 S homeolog Protein, SET and MYND domain containing 2a Protein, SET and MYND domain containing 2b Protein, SMYD2 Protein, Smyd2 Protein, smyd2.S Protein, smyd2a Protein, smyd2b Protein

Sujet:

Background: SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cells differentiation. SMYD2 mRNA is most highly expressed in heart and brain tissue. Over-expressed SMYD2 localizes to the cytoplasm and the nucleus in 293T cells. SMYD2 appears to restrain cell proliferation, likely through direct modulation of chromatin structure. Patients with SMYD2-overexpressing tumors had a worse overall rate of survival than those with non-expressing tumors, and SMYD2 positivity was independently associated with a worse outcome in the multivariate analysis. SMYD2 plays an important role in tumor cell proliferation through its activation/overexpression and regards as a prognosticator and potential therapeutic target in esophageal squamous cell carcinoma (ESCC).

Synonym: HSKM-B,KMT3C,ZMYND14

Poids moléculaire: 52 kDa

NCBI Accession: NP_064582