SLITRK1 Protein (His tag,Fc Tag)

N° du produit ABIN7317905

Détail du produit

Antigène: SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette SLITRK1 protéine est marqué à la His tag,Fc Tag.

Fonction: Recombinant Human SLITRK1 Protein (His & Fc Tag)

Séquence: Met 1-Ser 616

Attributs du produit: A DNA sequence encoding the extracellular domain (Met 1-Ser 616) of human SLITRK1 (NP_443142.1) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 50 mM Tris, pH 7.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))

Autre désignation: SLITRK1 (SLITRK1 Produits)

Synonymes: DKFZp459G0529 Protein, LRRC12 Protein, TTM Protein, 3200001I04Rik Protein, SLIT and NTRK like family member 1 Protein, SLIT and NTRK-like family, member 1 Protein, SLITRK1 Protein, slitrk1 Protein, Slitrk1 Protein

Sujet:

Background: SLITRK1 (Slit and Trk-like family member 1) is a integral membrane protein belonging to the SLITRK family consists of at least 6 members (SLITRK1-6). They are named and characterized by the presence of two leucine-rich repeats (LRRs) in the extracellular domain similar to those found in a secreted axonal growth-controlling protein, Slit, as well as a C-terminal domain with homology to Trk neurotrophin tyrosine kinase receptors. Expression of SLITRKs are highly restricted to neural tissues, and are identified as the neuronal components modulating the neurite outgrowth. More specifically, SLITRK1 expression is found in the mature neurons of the cerebrum, thalamus and hippocampus, and induces unipolar neurites in cultured neuronal cells. Human SLITRK1 is a 696 amino acid precursor protein, and one truncating frameshift mutation (448 aa) has been linked to Tourette's syndrome, a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. In addition, all SLITRK genes are differentially expressed in brain tumors, such as astrocytoma, oligodendroglioma, glioblastoma, and are suggested to be useful molecular indicators of brain tumor properties.

Synonym: FLJ54428,KIAA0918,KIAA1910,LRRC12,RP11-395N17.1,SLITRK1,TTM

Poids moléculaire: 95 kDa

NCBI Accession: NP_443142