SPARCL1 Protein (His tag)

N° du produit ABIN7320238

Détail du produit

Antigène: SPARCL1 (SPARC-Like 1 (Hevin) (SPARCL1))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette SPARCL1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse SPARCL1/SPARC-like 1 Protein (His Tag)

Séquence: Tyr368-Phe650

Attributs du produit: A DNA sequence encoding the mouse Sparcl1 (NP_034227.3) (Tyr368-Phe650) was expressed with a polyhistidine tag at the N-terminus.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SPARCL1 (SPARC-Like 1 (Hevin) (SPARCL1))

Autre désignation: SPARCL1/SPARC-like 1 (SPARCL1 Produits)

Synonymes: LOC445896 Protein, SPARCL1 Protein, sparcl Protein, sparcl1 Protein, DKFZp459I2327 Protein, Ecm2 Protein, Sc1 Protein, hevin Protein, mast9 Protein, PIG33 Protein, SC1 Protein, SPARCL-1 Protein, SPARCL1 Protein, SPARC like 1 Protein, SPARC-like 1 Protein, SPARC-like protein 1 Protein, LOC445896 Protein, SPARCL1 Protein, sparcl1 Protein, Sparcl1 Protein

Sujet:

Background: SPARC-like protein 1 (SPARCL1, also known as SC1, high endothelial venule protein, or hevin) is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis. SPARCL1 has antiadhesive properties, and loss of SPARCL1 expression is associated with increased proliferative activity and cell cycle progression. It is suggested that it may influence multiple cellular processes during distinct stages of brain development and function. In addition, SPARCL1 can influence the function of astroglial cells in the developing and mature central nervous system (CNS).

Synonym: Ecm2,hevin,mast9,Sc1

Poids moléculaire: 34.8 kDa

NCBI Accession: NP_034227