SDC4 Protein (AA 1-146) (His tag)

N° du produit ABIN7320170

Détail du produit

Antigène: SDC4 (Syndecan 4 (SDC4))

Type de proteíne: Recombinant

Attributs du protein: AA 1-146

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette SDC4 protéine est marqué à la His tag.

Fonction: Recombinant Mouse Syndecan-4/SDC4 Protein (aa 1-146, His Tag)

Séquence: Met 1-Val 146

Attributs du produit: A DNA sequence encoding the mouse SDC4 (O35988) extracellular domain (Met 1-Val 146) was expressed, fused with a C-terminal polyhistidine tag.

Pureté: > 95 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: SDC4 (Syndecan 4 (SDC4))

Autre désignation: Syndecan-4/SDC4 (SDC4 Produits)

Synonymes: SYND4 Protein, AA959608 Protein, AW108331 Protein, Synd4 Protein, ryudocan Protein, syndecan-4 Protein, RATRYUDOCA Protein, RYUDOCA Protein, SDC4 Protein, sdc4l Protein, wu:fc47g09 Protein, Syndecan-4 Protein, amphiglycan Protein, syn-4 Protein, syn4 Protein, syndecan 4 Protein, syndecan 4 S homeolog Protein, syndecan 4 L homeolog Protein, SDC4 Protein, Sdc4 Protein, sdc4 Protein, sdc4.S Protein, sdc4.L Protein

Sujet:

Background: SDC4 (Syndecan-4), also known as Syn4, is a transmembrane heparan sulfate proteoglycan that co-operates with integrins during cell-matrix interactions for the assembly of focal adhesions and actin stress fibers and in the phosphorylation of focal adhesion kinase (FAK) on Tyr397. Syndecan-4 plays roles in the formation of focal adhesions and stress fibers. The cytoplasmic domain of syndecan-4 interacts with a number of signalling and structural proteins, and both extracellular and cytoplasmic domains are necessary for regulated activation of associated transmembrane receptors. Syndecan-4/SDC4 is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. SDC4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. Therefore, SDC4 may be a novel therapeutic target for preventing arterial restenosis after angioplasty.

Synonym: AA959608,AW108331,ryudocan,Synd4,syndecan-4,SDC4,SYND4,Ryudocan core protein

Poids moléculaire: 14.9 kDa

UniProt: O35988

Pathways: Glycosaminoglycan Metabolic Process