TDGF1 Protein (Fc Tag)

N° du produit ABIN7198209

Détail du produit

Antigène: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Purification/Conjugué: Cette TDGF1 protéine est marqué à la Fc Tag.

Fonction: Recombinant Rat TDGF1 Protein (Fc Tag)

Séquence: Met 1-Cys 143

Attributs du produit: A DNA sequence encoding the rat TDGF1 (XP_001056317.2) (Met 1-Cys 143) was fused with the Fc region of human IgG1 at the C-terminus.

Pureté: > 90 % as determined by SDS-PAGE

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Autre désignation: TDGF1 (TDGF1 Produits)

Synonymes: CR Protein, CRGF Protein, CRIPTO Protein, CR1 Protein, cripto Protein, cb85 Protein, tdgf1 Protein, wu:fe01d04 Protein, zgc:109829 Protein, Cripto-1 Protein, cr1 Protein, cr1a Protein, frl-1 Protein, frl1 Protein, xcr1 Protein, TDGF1 Protein, tdgf3 Protein, cripto-3 Protein, teratocarcinoma-derived growth factor 1 Protein, teratocarcinoma-derived growth factor 1, member 3 L homeolog Protein, teratocarcinoma-derived growth factor 1, member 1 Protein, TDGF1 Protein, Tdgf1 Protein, tdgf1 Protein, tdgf1.3.L Protein, tdgf1.1 Protein

Sujet:

Background: Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in Cripto/TDGF1 can cause autosomal visceral heterotaxy. Cripto/TDGF1 is involved in left-right asymmetric morphogenesis during organ development. Cripto signalling is essential for the conversion of a proximal–distal asymmetry into an orthogonal anterior–posterior axis. The mechanism of inhibitory effects of the Cripto includes both cancer cell apoptosis, activation of c-Jun-NH(2)-terminal kinase and p38 kinase signaling pathways and blocking of Akt phosphorylation. Thus, Cripto is a unique target, and Immunohistochemistry to Cripto could be of therapeutic value for human cancers.

Synonym: FGFR-4

Poids moléculaire: 41 kDa

NCBI Accession: XP_001056317

Pathways: EGFR Signaling Pathway