TXN2 Protein (His tag)
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- Antigène Voir toutes TXN2 Protéines
- TXN2 (Thioredoxin 2 (TXN2))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette TXN2 protéine est marqué à la His tag.
- Fonction
- Recombinant Human Thioredoxin-2/TXN2 Protein (His Tag)(Active)
- Séquence
- Thr 60-Gly 166
- Attributs du produit
- A DNA sequence encoding the mature form of human TXN2 (Q99757) (Thr 60-Gly 166) was expressed, with a polyhistide tag at the N-terminus.
- Pureté
- > 97 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- Measured by its ability to catalyze the reduction of insulin. The reaction leads to precipitation, which can be measured by absorbance at 650 nm. The specific activity is 5-8 A650/min/mg.
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- Discover our top product TXN2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 8.3
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Antigène
- TXN2 (Thioredoxin 2 (TXN2))
- Autre désignation
- Thioredoxin-2/TXN2 (TXN2 Produits)
- Synonymes
- MT-TRX Protein, MTRX Protein, TRX2 Protein, 31884 Protein, CG31884 Protein, CG3864 Protein, DTrx-2 Protein, DmTrx-2 Protein, DmelTrx-2 Protein, Dmel\\CG31884 Protein, Trx Protein, anon-WO0118547.188 Protein, dmtrx-2 Protein, 2510006J11Rik Protein, AI788873 Protein, Trx2 Protein, zgc:77127 Protein, thioredoxin 2 Protein, thioredoxin-2 Protein, thiol reductase thioredoxin Protein, thioredoxin 2 L homeolog Protein, TXN2 Protein, Trx-2 Protein, LOC409451 Protein, VPA0972 Protein, VS_RS18125 Protein, VCD_000568 Protein, VEA_000083 Protein, trx2 Protein, Txn2 Protein, txn2 Protein, txn2.L Protein
- Sujet
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Background: Thioredoxin-2; also known as TXN2; MTRX and TRX2; is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which; as trypanothione:peroxiredoxin oxidoreductases; constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses; as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.
Synonym: Thioredoxin Mitochondrial; MTRX; Mt-Trx; Thioredoxin-2; TXN2; TRX2
- Poids moléculaire
- 13.4 kDa
- UniProt
- Q99757
- Pathways
- Cell RedoxHomeostasis
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