TGFBR1 Protein (Fc Tag)

N° du produit ABIN7320892

Détail du produit

Antigène: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Purification/Conjugué: Cette TGFBR1 protéine est marqué à la Fc Tag.

Fonction: Recombinant Mouse ALK-5/TGFBR1 (C-Fc)

Séquence: Leu30-Glu125

Attributs du produit: Recombinant Mouse TGF-beta Receptor Type-1 is produced by our Mammalian expression system and the target gene encoding Leu30-Glu125 is expressed with a Fc tag at the C-terminus.

Pureté: >95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))

Autre désignation: ALK-5/TGFBR1 (TGFBR1 Produits)

Synonymes: AAT5 Protein, ACVRLK4 Protein, ALK-5 Protein, ALK5 Protein, LDS1A Protein, LDS2A Protein, MSSE Protein, SKR4 Protein, TGFR-1 Protein, aat5 Protein, acvrlk4 Protein, alk-5 Protein, alk5 Protein, lds1a Protein, lds2a Protein, skr4 Protein, tgfr-1 Protein, TGFBR1 Protein, x-trr1 Protein, AU017191 Protein, Alk-5 Protein, TbetaR-I Protein, TbetaRI Protein, Alk5 Protein, Skr4 Protein, Tgfr-1 Protein, tbetaR-I Protein, tgfbr1 Protein, zgc:123263 Protein, transforming growth factor beta receptor 1 Protein, transforming growth factor beta receptor I Protein, transforming growth factor beta receptor I S homeolog Protein, transforming growth factor, beta receptor I Protein, transforming growth factor, beta receptor 1 Protein, transforming growth factor, beta receptor 1 a Protein, TGFBR1 Protein, tgfbr1 Protein, tgfbr1.S Protein, Tgfbr1 Protein, tgfbr1a Protein

Sujet:

Background: TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models in vivo. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers, with the majority of colon and gastric cancers being caused by an inactivating mutation of TGF-beta RII. TGF-beta RI is likely important during development, since mice deficient for TGF-beta RI die at midgestation with severe defects in vascular development of the yolk sac and placenta, and an absence of circulating red blood cells. Furthermore, TGF-beta RI appears to be involved in proper lymphatic network development.

Synonym: AAT5, activin A receptor type II-like kinase, 53kD, ACVRLK4, ALK-5, ALK-5ALK5, LDS1A, LDS2A, SKR4, tbetaR-I, TGFB1R1, TGF-beta receptor type I, TGFbetaRI, TGFBR1, TGF-bRI, TGFR-1

Poids moléculaire: 37.6 kDa

UniProt: Q64729

Pathways: Growth Factor Binding