UBE2G2 Protein (GST tag)

N° du produit ABIN7319148

Détail du produit

Antigène: UBE2G2 (Ubiquitin-Conjugating Enzyme E2G 2 (UBE2G2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette UBE2G2 protéine est marqué à la GST tag.

Fonction: Recombinant Human UBE2G2 Protein (GST Tag)

Séquence: Met 1-Leu165

Attributs du produit: Recombinant Human Ubiquitin-Conjugating Enzyme E2 G2 is produced by our E.coli expression system and the target gene encoding Met1-Leu165 is expressed with a GST tag at the N-terminus.

Pureté: > 95 % as determined by reducing SDS-PAGE.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, 2 mM DTT, 10 % Glycerol, pH 7.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: UBE2G2 (Ubiquitin-Conjugating Enzyme E2G 2 (UBE2G2))

Autre désignation: UBE2G2 (UBE2G2 Produits)

Synonymes: UBC7 Protein, 1110003O05Rik Protein, D10Xrf369 Protein, Ubc7p Protein, wu:fu51c05 Protein, wu:fu56g11 Protein, zgc:112077 Protein, ubc7 Protein, ube2g1 Protein, ube2g2 Protein, wu:fi33c04 Protein, zgc:55974 Protein, ubiquitin conjugating enzyme E2 G2 Protein, ubiquitin-conjugating enzyme E2G 2 Protein, ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) Protein, ubiquitin-conjugating enzyme E2 G2 Protein, Ubiquitin-conjugating enzyme E2 G2 Protein, ubiquitin conjugating enzyme E2 G2 L homeolog Protein, ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast) Protein, UBE2G2 Protein, Ube2g2 Protein, ube2g2 Protein, EDI_023910 Protein, CpipJ_CPIJ018658 Protein, Bm1_47630 Protein, ube2g2.L Protein, ube2g1a Protein

Sujet:

Background: Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60 % and 100 % sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 Molecules into close proximity which allows for Ub transfer between neighboring E2s.

Synonym: Ubiquitin-Conjugating Enzyme E2 G2, Ubiquitin Carrier Protein G2, Ubiquitin-Protein Ligase G2, UBE2G2

Poids moléculaire: 45.0 kDa

UniProt: P60604