WTAP Protein (GST tag)

N° du produit ABIN7317433

Détail du produit

Antigène: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette WTAP protéine est marqué à la GST tag.

Fonction: Recombinant Human WTAP Protein (GST Tag)

Séquence: Met 1-Arg 151

Attributs du produit: A DNA sequence encoding the human WTAP isoform 2 (Q15007-2) (Met 1-Arg 151) was fused with the GST tag at the N-terminus.

Pureté: > 90 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 0.15M NaCl, 0.5 mM GSH, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Autre désignation: WTAP (WTAP Produits)

Synonymes: MGC75954 Protein, WTAP Protein, RGD1563824 Protein, wu:fi29a09 Protein, zgc:66202 Protein, 2810408K05Rik Protein, 9430038B09Rik Protein, WT1 associated protein Protein, Wilms tumor 1 associated protein Protein, wilms tumor 1 associated protein Protein, WT1 associated protein L homeolog Protein, Wilms tumour 1-associating protein Protein, wtap Protein, WTAP Protein, CpipJ_CPIJ006489 Protein, Wtap Protein, wtap.L Protein

Sujet:

Background: Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, stabilization of mRNA, and cell growth. Knocking down endogenous WTAP increased Smooth muscle cells (SMCs) proliferation, because of increased DNA synthesis and G(1)/S phase transition, together with reduced apoptosis. These effects could be the result of WTAP suppressing the transcriptional activity of WT1 in SMCs. WTAP may thus also play a role in messenger RNA processing in mammalian cells, either dependent on or independent of its interaction with WT1.

Synonym: Mum2

Poids moléculaire: 45 kDa