ADAM8 Protein (AA 17-655) (His tag)

N° du produit ABIN7273801

Détail du produit

Antigène: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Type de proteíne: Recombinant

Attributs du protein: AA 17-655

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette ADAM8 protéine est marqué à la His tag.

Fonction: Human ADAM8 Protein

Séquence: Ile17-Pro655

Attributs du produit: Recombinant Human ADAM8 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ile17-Pro655.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human ADAM8, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-ADAM8 Antibody, hFc Tag with the EC50 of 4.0ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: ADAM8 (ADAM Metallopeptidase Domain 8 (ADAM8))

Autre désignation: ADAM8 (ADAM8 Produits)

Synonymes: CD156 Protein, MS2 Protein, CD156a Protein, E430039A18Rik Protein, adam8 Protein, reprolysin Protein, si:zc217g15.7 Protein, zgc:64059 Protein, ADAM8 Protein, RGD1566394 Protein, ADAM metallopeptidase domain 8 Protein, a disintegrin and metalloproteinase domain 8 Protein, a disintegrin and metallopeptidase domain 8 Protein, ADAM metallopeptidase domain 8a Protein, ADAM8 Protein, LOC100304737 Protein, Adam8 Protein, adam8a Protein, adam8 Protein

Sujet: A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer.

Poids moléculaire: 70.9 kDa same as Tris-Bis PAGE result.

UniProt: P78325

Pathways: Activation of Innate immune Response, M Phase