AMIGO2 Protein (AA 39-397) (His tag)

N° du produit ABIN7273828

Détail du produit

Antigène: AMIGO2 (Adhesion Molecule with Ig-Like Domain 2 (AMIGO2))

Type de proteíne: Recombinant

Attributs du protein: AA 39-397

Origine: Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: Cette AMIGO2 protéine est marqué à la His tag.

Fonction: Cynomolgus AMIGO2 Protein

Séquence: Val39-Thr397

Attributs du produit: Recombinant Cynomolgus AMIGO2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val39-Thr397.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: AMIGO2 (Adhesion Molecule with Ig-Like Domain 2 (AMIGO2))

Autre désignation: AMIGO2 (AMIGO2 Produits)

Synonymes: AMIGO2 Protein, AI415330 Protein, AMIGO-2 Protein, AW208913 Protein, Ali1 Protein, ALI1 Protein, DEGA Protein, adhesion molecule with Ig like domain 2 Protein, adhesion molecule with Ig-like domain 2 Protein, AMIGO2 Protein, Amigo2 Protein

Sujet: Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis.

Poids moléculaire: 41.97 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

UniProt: G7PHN7