FcRn Protein (AA 22-297) (His tag)
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- Antigène Voir toutes FcRn Protéines
- FcRn (IgG receptor FcRn (FcRn))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 22-297
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Origine
- Souris
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette FcRn protéine est marqué à la His tag.
- Fonction
- Mouse FcRn Protein
- Séquence
- Ser22-Ser297 (FCGRT) & Ile21-Met119 (B2M)
- Specificité
- Uni-Prot: Q61559 (FCGRT), P01887 (B2M)
- Attributs du produit
- Recombinant Mouse FcRn Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser22-Ser297 (FCGRT) & Ile21-Met119 (B2M).
- Pureté
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 4.55 nM as determined in SPR assay (Biacore T200). See testing image for detail.
- Top Product
- Discover our top product FcRn Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- FcRn (IgG receptor FcRn (FcRn))
- Autre désignation
- FcRn (FcRn Produits)
- Synonymes
- FCRN Protein, alpha-chain Protein, FcRn Protein, Fc fragment of IgG receptor and transporter Protein, Fc receptor, IgG, alpha chain transporter Protein, FCGRT Protein, Fcgrt Protein
- Sujet
- The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
- Poids moléculaire
- 32.1 kDa (FCGRT)&11.7 kDa (B2M). Due to glycosylation, the protein migrates to 50-55 kDa (FCGRT)&14-15 kDa (B2M) based on Tris-Bis PAGE result.
- UniProt
- Q61559
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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