GP6 Protein (AA 21-251) (His tag)

N° du produit ABIN7274759

Détail du produit

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Type de proteíne: Recombinant

Attributs du protein: AA 21-251

Origine: Cynomolgus

Source: HEK-293 Cells

Purification/Conjugué: Cette GP6 protéine est marqué à la His tag.

Fonction: Cynomolgus GPVI Protein

Séquence: Gln21-Asn251

Attributs du produit: Recombinant Cynomolgus GPVI Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln21-Asn251.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Cynomolgus GPVI, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-GPVI Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Autre désignation: GPVI (GP6 Produits)

Synonymes: BDPLT11 Protein, GPIV Protein, GPVI Protein, 9830166G18Rik Protein, Gm469 Protein, Gpvi Protein, GP6 Protein, glycoprotein VI platelet Protein, glycoprotein 6 (platelet) Protein, glycoprotein VI Protein, platelet glycoprotein VI Protein, GP6 Protein, Gp6 Protein, LOC103346235 Protein

Sujet: Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.

Poids moléculaire: 26.42 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.

NCBI Accession: XP_005590417