IL18BP Protein (AA 31-194) (His tag)
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- Antigène Voir toutes IL18BP Protéines
- IL18BP (Interleukin 18 Binding Protein (IL18BP))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 31-194
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette IL18BP protéine est marqué à la His tag.
- Fonction
- Human IL-18BP Protein
- Séquence
- Thr31-Gly194
- Attributs du produit
- Recombinant Human IL-18BP Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr31-Gly194.
- Pureté
- > 95 % as determined by Tris-Bis PAGE
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 0.26nM as determined in SPR assay (Biacore T200). See testing image for detail.
- Top Product
- Discover our top product IL18BP Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- IL18BP (Interleukin 18 Binding Protein (IL18BP))
- Autre désignation
- IL-18BP (IL18BP Produits)
- Synonymes
- IL18BP Protein, IL-18BP Protein, Igifbp Protein, MC54L Protein, IL18BPa Protein, interleukin 18 binding protein Protein, IL18BP Protein, Il18bp Protein
- Sujet
- Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
- Poids moléculaire
- 18.7 kDa. Due to glycosylation, the protein migrates to 40-60 kDa based on Tris-Bis PAGE result.
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