PLGF Protein (AA 19-221) (Fc Tag)

N° du produit ABIN7275444

Détail du produit

Antigène: PLGF (PGF) (Placenta Growth Factor (PGF))

Type de proteíne: Recombinant

Attributs du protein: AA 19-221

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette PLGF protéine est marqué à la Fc Tag.

Fonction: Human PGF Protein

Séquence: Leu19-Arg221

Attributs du produit: Recombinant Human PGF Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Leu19-Arg221.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human PGF, hFc Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Human VEGF R1, His Tag with the EC50 of 12.8ng/ml determined by ELISA. See testing image for detail.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: PLGF (PGF) (Placenta Growth Factor (PGF))

Autre désignation: PGF (PGF Produits)

Synonymes: D12S1900 Protein, PGFL Protein, PLGF Protein, PlGF-2 Protein, SHGC-10760 Protein, AI854365 Protein, PIGF Protein, Plgf Protein, PlGF Protein, placental growth factor Protein, placenta growth factor Protein, PGF Protein, Pgf Protein, PLGF Protein

Sujet: Placental growth factor (PGF) is another member of the VEGF family of cytokines with pro-angiogenic and pro-inflammatory effects. Retinal inhibition of PGF in combination with VEGF-A prevents vascular leakage and CNV possibly via modulating their own expression in mononuclear phagocytes. PGF-related, optimized strategies to target inflammation-mediated angiogenesis may help to increase efficacy and reduce non-responders in the treatment of wet AMD patients.

Poids moléculaire: 48.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

Pathways: VEGFR1 Specific Signals