SEZ6 Protein (AA 20-927) (His tag)
-
- Antigène Voir toutes SEZ6 Protéines
- SEZ6 (Seizure Related 6 Homolog (SEZ6))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 20-927
-
Origine
- Cynomolgus
-
Source
- HEK-293 Cells
- Purification/Conjugué
- Cette SEZ6 protéine est marqué à la His tag.
- Fonction
- Cynomolgus SEZ6 Protein
- Séquence
- Leu20-His927
- Attributs du produit
- Recombinant Cynomolgus SEZ6 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu20-His927.
- Pureté
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Stérilité
- 0.22 μm filtered
- niveau d'endotoxine
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Cynomolgus SEZ6, His Tag at 5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 22.7ng/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product SEZ6 Protéine
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- SEZ6 (Seizure Related 6 Homolog (SEZ6))
- Autre désignation
- SEZ6 (SEZ6 Produits)
- Synonymes
- BSRP-C Protein, D11Bhm177e Protein, mKIAA4158 Protein, sez-6 Protein, seizure related gene 6 Protein, seizure related 6 homolog Protein, Sez6 Protein, SEZ6 Protein
- Sujet
- Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
- Poids moléculaire
- 99.11 kDa. Due to glycosylation, the protein migrates to 150-180 kDa based on Tris-Bis PAGE result.
- UniProt
- A0A2K5WPJ4
- Pathways
- Synaptic Membrane
-