IL-3 Protein (His tag)

N° du produit ABIN7447933

Cette protéine Recombinant IL-3 est produite dans HEK-293 Cells.

Aperçu rapide pour IL-3 Protein (His tag) (ABIN7447933)

Antigène: IL-3 (Interleukin 3 (IL-3))

Type de proteíne: Recombinant

Origine: Cynomolgus

Source: HEK-293 Cells

Pureté: 90,00 %

Détail du produit

Purification/Conjugué: Cette IL-3 protéine est marqué à la His tag.

Fonction: Cynomolgus IL-3 Protein, His Tag

Séquence: Ala 20 -Gln 143

Attributs du produit: Cynomolgus IL-3, His Tag is expressed from human 293 cells (HEK293). It contains AA Ala 20 -Gln 143 (Accession # G7P877-1).

niveau d'endotoxine: 1.0 EU per μg

Information d'application

Commentaires:

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 18-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: IL-3 (Interleukin 3 (IL-3))

Autre désignation: IL-3

Sujet: Synonyms:IL3,MCGF,MGC79398,MGC79399,MULTI-CSF,Interleukin-3,Description:Interleukin 3 is also known as IL-3, is a protein that in humans is encoded by the IL3 gene. Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor. The IL-3 receptor is a heterodimer of the IL-3 specific α-chain and the common β-chain, βc, which is also used by GM-CSF and IL-5. [3] Binding of IL-3 can also involve substitution of the βc by a βIL-3-chain that appears to be specific for IL-3 . Binding of IL-3 to its cognate receptor(s) induces activation of Jak2, phosphorylation of multiple Stats, and the PI3K/Akt pathway. IL-3 may play an important role in the development of airway inflammation associated with asthma. The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.

Poids moléculaire: 15.9 kDa

Pathways: Signalistation JAK/STAT, Regulation of Carbohydrate Metabolic Process, Autophagy