KIT Ligand Protein (KITLG) (AA 26-189)

N° du produit ABIN7447897

Cette protéine Recombinant KIT Ligand est produite dans HEK-293 Cells.

Aperçu rapide pour KIT Ligand Protein (KITLG) (AA 26-189) (ABIN7447897)

Antigène: KIT Ligand (KITLG)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: 90,00 %

Détail du produit

Attributs du protein: AA 26-189

Fonction: Human SCF / KITLG (26-189) Protein, premium grade

Marque: Premium grade

Séquence: Glu 26 - Ala 189

Attributs du produit: Human SCF (26-189), premium grade is expressed from human 293 cells (HEK293). It contains AA Glu 26 - Ala 189 (Accession # P21583-1).
Premium grade: This product is produced under rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage.

Stérilité: Sterile

niveau d'endotoxine: 0.1 EU per μg

Information d'application

Commentaires:

This protein carries no "tag". The protein has a calculated MW of 18.5 kDa. The protein migrates as 20-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: KIT Ligand (KITLG)

Autre désignation: SCF

Sujet: Synonyms:KITLG,FPH2,KL-1,Kitl,MGF,SCF,SF,SHEP7,KL,Description:Stem Cell Factor is also known as SCF, kit-ligand, KL, steel factor, KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, or SHEP7, and is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. The soluble and transmembrane forms of the protein are formed by alternative splicing of the same R transcript.Soluble and transmembrane SCF is produced by fibroblasts and endothelial cells. Soluble SCF has a molecular weight of 18,5 KDa and forms a dimer. SCF plays an important role in the hematopoiesis during embryonic development. Sites where hematopoiesis takes place, such as the fetal liver and bone marrow, all express SCF. During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors. The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.

Poids moléculaire: 18.5 kDa

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway