Aggrecan Protein (ACAN) (AA 17-721) (His tag)

N° du produit ABIN7454069

Détail du produit

Antigène: Aggrecan (ACAN)

Type de proteíne: Recombinant

Attributs du protein: AA 17-721

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Aggrecan protéine est marqué à la His tag.

Fonction: Human Aggrecan Protein

Séquence: Ala17-Leu721

Attributs du produit: Recombinant Human Aggrecan Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala17-Leu721.

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Aggrecan (ACAN)

Autre désignation: Aggrecan (ACAN Produits)

Synonymes: AGC1 Protein, AGCAN Protein, CSPG1 Protein, CSPGCP Protein, MSK16 Protein, SEDK Protein, Agc Protein, Agc1 Protein, Cspg1 Protein, b2b183Clo Protein, cmd Protein, aggrecan Protein, aggrecan core protein Protein, ACAN Protein, Acan Protein, LOC100380783 Protein, AGC Protein

Sujet: Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vessels during cardiovascular development. Whereas aggrecan is essential for skeletal development, its function in the developing cardiovascular system remains to be fully elucidated.

Poids moléculaire: 78.86 kDa. Due to glycosylation, the protein migrates to 90-130 kDa based on Tris-Bis PAGE result.

UniProt: Q6PID9

Pathways: Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport