Zona Pellucida Glycoprotein 3 Protein (ZP3) (His tag)

N° du produit ABIN7490852

Détail du produit

Antigène: Zona Pellucida Glycoprotein 3 (ZP3)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Zona Pellucida Glycoprotein 3 protéine est marqué à la His tag.

Fonction: Recombinant human ZP3 protein with C-terminal 6xHis tag

Specificité: ZP3 (Gln23-Ser386) 6xHis tag

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: Zona Pellucida Glycoprotein 3 (ZP3)

Autre désignation: ZP3 (ZP3 Produits)

Synonymes: ZP3A Protein, ZP3B Protein, ZPC Protein, Zp-3 Protein, zp3.2 Protein, Zp-3B Protein, zona pellucida glycoprotein 3 Protein, zona pellucida sperm-binding protein 3 Protein, ZP3 Protein, zp3 Protein, Zp3 Protein

Sujet: Zona pellucida sperm-binding protein 3,Sperm receptor,ZP3A/ZP3B,Zp-3,Zona pellucida protein CThe zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development.
Description: The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

Poids moléculaire: predicted molecular mass of 66.6 kDa after removal of the signal peptide. The apparent molecular mass of ZP3-His is 100-130 kDa due to glycosylation.

UniProt: P21754

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process