MRGPRX2 Protein (Fc Tag)

N° du produit ABIN7491443

Détail du produit

Antigène: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette MRGPRX2 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human MRGPRX2 Protein with C-terminal human Fc tag

Specificité: MRGPRX2 (Met1-Pro33) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Autre désignation: MRGPRX2 (MRGPRX2 Produits)

Synonymes: MRGX2 Protein, G370024M05Rik Protein, MrgB10 Protein, Mrgprb10 Protein, MrgB1 Protein, Mrgprb1 Protein, MAS related GPR family member X2 Protein, MAS-related GPR, member X2 Protein, MRGPRX2 Protein, Mrgprx2 Protein

Sujet: MGRG3, MRGX2Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.[UniProtKB/Swiss-Prot Function]

Poids moléculaire: predicted molecular mass of 29.6 kDa after removal of the signal peptide. The apparent molecular mass of MRGPRX2-hFc is 35-55 kDa due to glycosylation.

UniProt: Q96LB1