GLP1R Protein (Fc Tag)

N° du produit ABIN7491459

Détail du produit

Antigène: GLP1R (Glucagon-Like Peptide 1 Receptor (GLP1R))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette GLP1R protéine est marqué à la Fc Tag.

Fonction: Recombinant Human GLP1R Protein with C-terminal human Fc tag

Specificité: GLP1R (Arg24-Glu139) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: GLP1R (Glucagon-Like Peptide 1 Receptor (GLP1R))

Autre désignation: GLP1R (GLP1R Produits)

Synonymes: GLP1R Protein, LOC100228311 Protein, GLP-1R Protein, GLP1Rc Protein, Glip Protein, RATGL1RCP Protein, glucagon like peptide 1 receptor Protein, glucagon-like peptide 1 receptor Protein, GLP1R Protein, Glp1r Protein

Sujet: GLP-1, GLP-1-R, GLP-1R
Description: This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Poids moléculaire: predicted molecular mass of 39.7 kDa after removal of the signal peptide. The apparent molecular mass of GLP1R-hFc is 35-70 kDa due to glycosylation.

UniProt: P43220

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, cAMP Metabolic Process, Feeding Behaviour