CMKLR1 Protéine

N° du produit ABIN7491613

Détail du produit

Antigène: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Type de proteíne: Synthetic

Origine: Humain

Source: HEK-293 Cells

Fonction: Human CMKLR1 full length protein-synthetic nanodisc

Attributs du produit: Full Length Transmembrane Proteins (synthetic Nanodisc)

Information d'application

Indications d'application:

• Applications for VLPs:
• ELISA
• SPR affinity analysis
• Phage display screening
• Immunization
• Cell based assays
• CAR-T cell screening
• Protein cystal structure analysis

Commentaires:

Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Autre désignation: CMKLR1 (CMKLR1 Produits)

Synonymes: CHEMERINR Protein, ChemR23 Protein, DEZ Protein, RVER1 Protein, Gpcr27 Protein, mcmklr1 Protein, si:ch211-240b21.3 Protein, CMLKR1 Protein, Cmklr-1 Protein, GPCR Protein, chemerin chemokine-like receptor 1 Protein, chemokine-like receptor 1 Protein, CMKLR1 Protein, Cmklr1 Protein, cmklr1 Protein

Sujet: CHEMERINR, ChemR23, DEZ, RVER1
Description: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).[UniProtKB/Swiss-Prot Function]

Poids moléculaire: The human full length CMKLR1 protein has a MW of 42.1 kDa

UniProt: Q99788